Mapping red nucleus connections in humans by using dMRI and tractography

Human brain is an enormous and complex network. Central to current scenario on brain networks is the concept of the connectome More »

Curiosity and flexibility help birds to master rapid environmental change

Birds are one of the most mobile organisms on earth due to their ability to fly. This allows them to use areas far apart for breeding and non-breeding More »

Virus chainmail: protective and porous metal-organic framework grown on a virus

Biomineralization describes a process of programmable accumulation, concentration, and construction of inorganic ions regulated by organisms to form both amorphous More »

Species are always important

This review is based on the premise that all species are important to life on earth even if the exact role or value of a species has not been formally documented More »

 

Molecular motion of propane in silica pores: computer simulations compared with neutron scattering experiments

Understanding how fluids, and notably hydrocarbon gases, seep through porous rocks in the terrestrial environment is essential to understand the fundamental processes involved and also to aid better recovery of these gases from the earth. It is

Myocardial stunning

How dose myocardial infarction develop? The myocardium is nourished from blood flowing in coronary arteries. When a coronary artery is abruptly occluded by a thrombus which develop at the site of a ruptured plaque or endothelial erosion,

Using glowing yeast to keep food safe

Dioxins and dioxin-like chemicals (DLCs) are a problematic group of pollutants that come from both natural and man-made origins. They do not easily break down on their own, which means that once they are present in an

How to detect dying neurons in the central nervous system?

The central nervous system (CNS) changes dynamically throughout an animal life. In the fruit fly, Drosophila melanogaster, asymmetric mitosis of the neuroblasts during embryonic development produces about 10,000 differentiated neurons that form a juvenile (larva) CNS. These

The 4th Annual Healthcare PPM Toolbox. New Jersey, USA. February 7 – 8, 2019

Continuous Success of Growing Ecosystems for Pharma and Medical Devices Professionals.Project and portfolio management is more important than ever for the pharmaceutical industry where the patent expiration war is in full swing. That is nothing new –

Sequencing of mtDNA of multiple single mitochondrion isolated from live cells identifies common heteroplasmic sites

Mitochondria are organelles present in all eukaryotic cells, including brain cells, and supply ATP required for cellular physiology through a series of redox reactions known as oxidative phosphorylation. They are unique in their requirement for expression of

The 9th Annual Pharma PPM Toolbox. Basel, Switzerland. March 7-8, 2019

The World’s Largest Conferencefor Pharma R&D Project & Portfolio Management Professionals.Project and portfolio management is more important than ever for the pharmaceutical industry where the patent expiration war is in full swing. That is nothing new –

Spindle associated membrane protein 1 (Samp1) in muscle differentiation

Skeletal muscles, the most common type of muscle in the body, are responsible for voluntary movements. Skeletal muscles are formed in a process called myogenesis (differentiation of muscles). During myogenesis a single-nucleus-myoblast (undifferentiated muscle cell) fuses with

Cholesterol manipulation switches the production of “toxic Aβ” to “protective Aβ”

The amyloid hypothesis maintains that the pathogenesis of Alzheimer’s disease (AD) is driven by the production and accumulation of amyloid-β (Aβ) peptides in the brain. Consequently, many therapeutic strategies to reduce Aβ production have been examined. However,

Polarized light therapy: Illuminating immunity

What is it?: Light has been used as an alternative mode for the treatment of diseases, since the ancient Egyptians basked in the sun to restore their energy. Phototherapies are modern treatments in which light is used

A new strategy against cancer cells. Targeting the Rho-GTPases interactions: The case of the new compound 1A116

For the last decades scientist have been working hard to find cancer´s Achilles heel to design and develop more specific and efficacious therapeutic strategies for cancer. It has become clear that altered cell signaling is a key

Estimating effects of new psychoactive substances (NPS) based on in vitro neurotoxicity data

The use of new psychoactive substances (NPS) is increasing and currently > 600 NPS have been reported. However, limited information on neuropharmacological and toxicological effects of NPS is available, hampering risk characterization. We reviewed the literature on

Bioartificial liver constructs

The liver with high regenerative capability performs a complex array of synthetic, metabolic, immunologic and detoxification functions to regulate the physiological homeostasis of the human body. Viral infections, drug induced liver injury, hepatocellular carcinoma, autoimmune disorders, alcoholic

The antibiotics of tomorrow: from enzyme Lego blocks to customized enzybiotics

Antibiotics play a key role in the treatment of bacterial infections and have saved millions of lives since their invention. Moreover, they allowed the development of complex surgeries and cancer treatments. However, already in 1945, after receiving

The role of oxidative stress in Type 2 diabetes

Type 2 diabetes is a major health concern that affects people no matter their gender, race, or socio-economic background is. In type 2 diabetes, a person’s body stops responding efficiently to insulin after a meal. This desensitization

Impact of digestion on the transport of macromolecule loaded nanoemulsion through intestine epithelium

The oral route, being the most convenient route for patients, has been extensively explored for the delivery of large molecular weight hydrophilic drugs. Oral delivery of macromolecules such as peptides and proteins has been a challenge due

Origin and fate of radionuclides in Swiss soils

Soils profiles from protected recharge fields used for drinking water production were drilled and analysed for radionuclides, such as radiocesium (137Cs), radiostrontium (90Sr) and plutonium (239+240Pu). Inventories and distribution of the radionuclides were compared with an uncultivated

Optimization of multi-omic genome-scale models

Metabolism is the set of biochemical reactions in a cell that maintain its living state. As these reactions are essential, it is vital that metabolic networks in all living organisms are well-characterized. This can be achieved by

Molecular mechanisms of gastrointestinal disorders caused by general anesthesia

Nowadays it is impossible to imagine surgery procedures without general anesthesia. From the wide variety of general anaesthetics both intravenous (such as propofol, ketamine, fentanyl etc.) and inhalation anesthetics (such as isoflurane, sevoflurane, desflurane etc.) are some

Oncogenic role of CircPVT1 in head and neck squamous cell carcinoma

Circular RNAs (circRNAs) are a class of endogenous non-coding RNAs that have recently shown to behave as gene regulators in eukaryotic cells, extending our previous knowledge regarding the diversity and complexity of the transcriptome. Nowadays, circRNAs have