Mapping red nucleus connections in humans by using dMRI and tractography

Human brain is an enormous and complex network. Central to current scenario on brain networks is the concept of the connectome More »

Curiosity and flexibility help birds to master rapid environmental change

Birds are one of the most mobile organisms on earth due to their ability to fly. This allows them to use areas far apart for breeding and non-breeding More »

Virus chainmail: protective and porous metal-organic framework grown on a virus

Biomineralization describes a process of programmable accumulation, concentration, and construction of inorganic ions regulated by organisms to form both amorphous More »

Species are always important

This review is based on the premise that all species are important to life on earth even if the exact role or value of a species has not been formally documented More »

 

Behind the journey to spawn of European eels: expression and role of adrenergic receptors during silvering

Adrenergic receptors

Eels make an astonishing journey to spawn, migrating from Europe to the Sargasso Sea, near Bermuda, and back again. After spawning, larvae are transported by the Gulf Stream to the continental shelf of Europe and North Africa,

Climate change and the unfeasibility of United Nations Sustainable Development Goals

Climate change and the unfeasibility

With recent upward trends in global temperatures and sea levels, many countries are experiencing higher rates of evapotranspiration, groundwater depletion, water salinity, and loss of habitats.  Moreover, increases in living standards entail higher consumption of animal products

Inhibitors of intracellular enzymes for treatment of multiple sclerosis

The protein kinase inhibitor imatinib

Lymphocytes are white blood cells that are central in the immune response to foreign microorganisms. Like all cells, lymphocytes have a membrane, a lipid bilayer, that envelops the content of the cell. Proteins attached to the cell

Finding the beta-beta residue pairing for protein structure prediction

protein structure prediction

Prediction of the tertiary structure of proteins from their amino acid sequences is of great importance and of urgent demand in structural bioinformatics and biophysics, especially considering the increasing gap between the numbers of sequences and structures

Repetitive DNA in the ABCA7 gene influences Alzheimer’s disease

Repetitive DNA in the ABCA7 gene influences Alzheimer’s disease

Dementia, which is characterized by decline of memory or other cognitive traits to the extent that a person’s daily functioning is affected, is one of the most important global health challenges of our time. Approximately 50 million

Objectivity applied to embodied subjects

Objectivity is a contested concept, especially when applied to human beings. Subjectivity is pervasive in human life, and personal passions and feelings are spices of daily existence. We argue that a cognitive concept of objectivity is appropriate

A new biomarker for Triple negative breast cancer MCP-1 drives cancer invasiveness and metastasis

Model of MCP-1 action in breast cancer cells

Breast Cancer is the second leading cause of mortality in women in the United States. Breast cancer arise in the ducts of the mammary glands that produces milk in a lactating breast. Breast cancers usually express various

Can historians work with environmental scientists? New insights for addressing climate change from interdisciplinary research

Data sources and characteristics

How can we uncover how past societies responded to and accommodated changes in their physical environment?  It is an important question, because climate change as well as natural events such as droughts, earthquakes and volcanic eruptions could

Advanced plasmonics: Self-assembly brings order

How to make perfectly ordered membrane without ordering

Nanoporous self-organized membranes are complex, sophisticatedly fabricated, hierarchical nanostructures which combine several unique properties such as very developed surface area and long pores through the whole free-standing or surface-bond films of several micrometers to several hundred micrometres

miR-146 and miR-155, two key modulators of the immune response and of the oncogenic transformation

miR-146 and miR-155, two key modulators of the immune response and of the oncogenic transformation

Micro-RNA (miRNAs or miRs) are small noncoding RNAs that negatively regulate protein coding gene transcripts and exert an important role in the control of gene expression. miRs are deregulated in many tumors and play an active role

Bone marrow chilling could warm the body

Bone marrow chilling could warm the body

In order to keep warm during cold exposure, heat production must be increased. This can be achieved through non-shivering and shivering thermogenesis. The main tissue involved in non-shivering thermogenesis is brown adipose tissue (BAT) which is located

Crossing borders to accelerate diagnosis of neurodegenerative diseases

Steps in biomarker development process

Neurodegenerative diseases of the Central Nervous System are affecting 50 million people worldwide. The forecast is that these numbers will steeply increase due to the aging population. These diseases are difficult to diagnose, due to a substantial

Parkinson disease: a tale of three neurotransmitters

The progressive loss of dopaminergic innervation of the basal ganglia, in particular of the dorsal striatum (putamen) is responsible for the motor signs of Parkinson disease such as bradykinesia, rigidity and loss of postural reflexes. Present therapies

No-bonding reactivity of Helium under pressure

The 1D model of He insertion into AB and A2B compounds

Noble gas (NG) elements have been thought historically to be chemically inert. Nevertheless, already in 1930, Pauling predicted that Xenon could react with other elements. Thirty years later, Bartlett synthetized the first Xe compound, Xe+[PtF6]–. High pressure

Disengaging ATF6 from DREAM for neuroprotection

Disengaging ATF6 from dream for neuroprotection

To study early changes in neuronal function during the pre-symptomatic phase of a given neurodegenerative disease is very important. It could deliver early diagnostic markers, offer prognostic clues about disease progression and uncover novel therapeutic targets for

Grandmothers’ breastfeeding stories to mothers: a knowledge translation gift

breastfeeding

Breastfeeding is an ideal way to feed babies that promotes and protects health throughout life. In the Northwest Territories, Canada, in follow-up to a study from one region of the territory, we conducted a territory-wide study to

Therapeutic delivery vehicle development by combinatorial post-modification

Schematic illustration of combinatorial polymer libraries synthesized by post-modification of reactive polymers for the optimization of therapeutic delivery polymers.

Polymers are widely used in the construction of nanocarriers for therapeutic delivery because of their precisely controllable structure and low toxicity. Combinatorially modified polymers usually have a portion of similar structures, while other specific structures determine the

Subjects with gambling-related problems requiring treatment

Subjects with Gambling-Related Problems Requiring Treatment

Gambling disorders affect 0.2–5.3% of adults worldwide, although measurement and prevalence varies according to the screening instruments and methods used, and the availability and accessibility of gambling opportunities. A significant percentage of gamblers develops clinically relevant gambling

Oral corticosteroids on hand to treat the next asthma exacerbation?

Outcome of asthma the years before and after oral corticosteroids were provided to parents for treatment of the next exacerbation.

Asthma exacerbations are a major cause of visits to an emergency room, especially for children. What is an asthma exacerbation? There is general agreement that acute symptoms of asthma become an exacerbation when they are more frequent

An educational programme for the control of hospital outbreaks

Healthcare associated infections due to microorganisms resistant to multiple antimicrobial drugs (Multidrug Resistant Organisms-MDROs) represent a concern for healthcare facilities worldwide. Because of the difficulties in the management of MDRO infections, various guidelines containing recommendations have been